Active studies

Active Studies


Enrolling (2019-2023)

120 participants

The Harness Study is a double-blind, randomized controlled trial

to assess the feasibility, acceptability, and effectiveness of an herbal supplement called kudzu to reduce alcohol use among individuals who drink alcohol. Participants will be randomly assigned to receive 12 weeks of kudzu extract (2 grams) or placebo, to be taken on an as-needed basis with follow-up visits at 1- and 3-months. Participants are seen weekly to complete study activities including receiving the study medication and counseling.

For more information, call (415) 437-6333,
email, or visit


Enrolling (2019-2023)

300 participants

The REBOOT 2.0 Study is a randomized controlled trial to assess the feasibility, acceptability, and effectiveness of a counseling intervention called Informational-Motivational-Behavioral-(IMB) based counseling to reduce opioid overdose risk among individuals who use opioids. Participants will be randomized to receive 30-45-minutes of overdose prevention IMB counseling or placebo. The study takes place in San Francisco, California, and Boston, Massachusetts. Participants are seen every 4 months for 16 months to complete study activities.

For more information, call (415) 437-6325,
email, or visit

Enrolling studies

Non-enrolling studies


Fully Enrolled (2018-2022)

300 participants

COPING is a five-year longitudinal cohort study of patients prescribed long-term opioids for chronic non-cancer pain. The study aims to better understand the impact that opioid prescribing changes have on pain, function, retention in medical care, and illicit substance use among patients with chronic pain.


Fully Enrolled (2016-2020)

600 participants

ODS is a retrospective chart review study to evaluate the impact that changes in opioid prescribing may have on the substance use and clinical care of patients in the San Francisco Health Network living with HIV compared to patients without HIV. The study utilizes extensive medical chart abstraction from patients who have recently been prescribed opioids at study initiation and again 2 years later.

FAQ about studies

Q:  Do you have any studies I can join?

Yes!  Scroll up to see our list of enrolling studies at the top of this page or email to learn more.

Q:  Can I enroll in more than one study at once?

Generally, we encourage people to participate in one study at the time, especially for studies that are researching interventions. For studies that do not involve interventions, it may be possible to participate in more than one study. Ask the study staff for more information. If you're participating in a study with a different organization and want to join one of our studies, our study staff can also discuss whether you are able to enroll in our study in more detail by phone.

Q:  Where do study activities take place?

All study activities take place at our office in San Francisco, CA, located on the 5th floor at 25 Van Ness (at the corner of Van Ness Avenue and Market Street).

Contact us

What would you like to do?

Q:  What are the risk and benefits of participating in a study?

There are different potential risks and benefits of participating in each study. You will learn about this during the screening process as you decide if the study is a good fit for you. In general, there is no guaranteed individual benefit to participating in research, as the interventions are still being tested. Your participation will hopefully lead to public health improvements that will benefit the larger community.

Q:  Will my privacy be protected?

Yes, we do our best to make sure your information is kept private. Personal information is stored in locking cabinets and secured databases. Upon enrolling in a study, you will receive a study ID which is what we will use on all study documentation instead of your name. The only individuals who may access your identifying information are study staff and monitoring agencies in the event of an audit. No data will be included in your medical record, nor disclosed to your provider or anyone outside the study team without your explicit consent, even in the case of a court-ordered subpoena.

Q:  Do I have to stop using substances to participate?

No, abstinence is not required for any of our studies. We follow the principles of harm reduction that aim to reduce the negative consequences associated with substance use while respecting the dignity and rights of those who use them.


San Francisco Department of Public Health

25 Van Ness Avenue, Suite 500
San Francisco, CA 94102


Tel: 628-217-6232

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CSUH is a program of the San Francisco Department of Public Health